ANAMNEZIDA HOMILA TUGʻMA NUQSONLAR VA HOMILANING OʻSISHDAN TOʻTASHI SINDROMI BOʻLGAN AYOLLARDA HOMILADORLIK KECHISHINING OʻZIGA XOSLIGI
Keywords:
hyperhomocysteinemia, congenital malformations of the fetus, undeveloped pregnancy, methylfolate.Abstract
Tadqiqot natijalari shuni ko'rsatdiki, anamnezida homila nuqsonlari va homila
o’sishdan to’xtash holati bo’lgan ayollarda pregravidar davrda metilfolat va B guruh
vitaminlarini qo’llash ko'rsatkichlarni sifat jihatidan ham, miqdoriy jihatdan ham
normallashtirishga imkon beradi, shuningdek, homila nuqsonlari, rivojlanmagan
homiladorlik, shuningdek gipergomosisteinemiyaga xos bo'lgan homiladorlik
asoratlarini rivojlanish xavfini sezilarli darajada kamaytiradi.Homiladorlik paytida
metilfolatning kofaktorlar bilan saplementatsiyasi rivojlanmagan homiladorlikni 1-
guruhda 6,6 marta, 2- guruhda 17,5 marta, platsenta disfunktsiyasini 1-guruhda 2,5
marta va 2-guruhda 1,5 marta kamaytirishga imkon berdi.
References
1. Achiron R, Adamo L, Kassif E. From screening chromosomal anomalies to early
diagnosis of fetal malformations. // Curr Opin Obstet Gynecol. 2020
Apr;32(2):128-133.
2. Chitayat D, Matsui D, Amitai Y, Kennedy D, Vohra S, Rieder M, Koren G. Folic
acid supplementation for pregnant women and those planning pregnancy: 2015
update. J Clin Pharmacol. 2016 Feb;56(2):170-5.
3. Dean SV, Lassi ZS, Imam AM, Bhutta ZA. Preconception care: nutritional risks
and interventions. // Reprod Health. 2014 Sep 26;1
4. Ferrazzi E, Tiso G, Di Martino D. Folic acid versus 5- methyl tetrahydrofolate
supplementation in pregnancy. Eur J Obstet Gynecol Reprod Biol. 2020
Oct;253:312-319.
5. Impellizzeri P, Nascimben F, Di Fabrizio D, Antonuccio P, Antonelli E, Peri FM,
Calabrese U, Arena S, Romeo C. Pathogenesis of Congenital Malformations:
Possible Role of Oxidative Stress. // Am J Perinatol. 2022 Jun;39(8):816-823.
doi: 10.1055/s-0040-1721081. Epub 2020 Nov 9.
6. Yangibayeva D.T., Yuldasheva D.Yu., Sadikova D.R., Choriyeva G.Z.,
Sadullayeva U.A. Influence of folate cycle MTHFR gene polymorphism on the
process of fetus development in residens of the republic Uzbekistan. World
Bulletin of public Health Volume 22, May 2023. P 43.
7. Yangibayeva D.T, Yuldasheva D.Yu., Sadikova D.R., Choriyeva G.Z.,
Sadullayeva U.A. Folat tsikli genlari polimorf variantlarining inson embrional
rivojlanishining dastlabki bosqichlari buzilishiga ta’siri. Вестник ТМА №9,
2022. Стр. 141-143