Vol. 4 No. 2 (2026), Articles
Vol. 4 No. 2 (2026)

ISCHEMIC STROKE: PATHOPHYSIOLOGY, DIAGNOSIS, AND MODERN THERAPEUTIC APPROACHES

Articles
Published 2026-02-14
Abduraupova Maftuna Yunusjon qizi
Termez University of Economics and Service Faculty of Medicine
PDF
DOI

Keywords

ischemic stroke, thrombolysis, thrombectomy, cerebral infarction, neuroprotection

How to Cite

ISCHEMIC STROKE: PATHOPHYSIOLOGY, DIAGNOSIS, AND MODERN THERAPEUTIC APPROACHES. (2026). MEDICINE, PEDAGOGY AND TECHNOLOGY: THEORY AND PRACTICE, 4(2), 100-103. https://universalpublishings.com/~niverta1/index.php/mpttp/article/view/16716
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver AMA

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Ischemic stroke is one of the leading causes of mortality and long-term disability worldwide. It occurs due to an abrupt interruption of cerebral blood flow, resulting in neuronal injury and brain infarction. Rapid diagnosis and timely reperfusion therapy are critical for improving outcomes. This article reviews the pathophysiology, diagnostic strategies, acute management, and long-term prognosis of ischemic stroke. Advances in thrombolysis and mechanical thrombectomy have significantly improved survival rates and neurological recovery. However, early recognition and prevention remain essential in reducing disease burden.

PDF
DOI

References

1. World Health Organization. Global report on stroke prevention and control. WHO; 2023.

2. Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO) Global Stroke Fact Sheet 2022. Lancet Neurol. 2022;21(10):795–820.

3. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of acute ischemic stroke. Stroke. 2019;50:e344–e418.

4. Goyal M, Menon BK, van Zwam WH, et al. Endovascular thrombectomy after large-vessel ischaemic stroke. N Engl J Med. 2015;372:2285–2295.

5. Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359:1317–1329.

6. Campbell BCV, De Silva DA, Macleod MR, et al. Ischaemic stroke. Nat Rev Dis Primers. 2019;5:70.

7. Saver JL. Time is brain—quantified. Stroke. 2006;37(1):263–266.

8. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008;371:1612–1623.

9. Benjamin EJ, Muntner P, Alonso A, et al. Heart Disease and Stroke Statistics—2023 Update. Circulation. 2023.

10. Campbell BCV, Khatri P. Stroke. Lancet. 2020;396:129–142.

11. European Stroke Organisation (ESO) Guidelines on mechanical thrombectomy. Eur Stroke J. 2021.

12. Amarenco P, Lavallée PC, Labreuche J, et al. One-year risk of stroke after TIA or minor stroke. N Engl J Med. 2016;374:1533–1542.

13. Dirnagl U, Iadecola C, Moskowitz MA. Pathobiology of ischemic stroke. Trends Neurosci. 1999;22(9):391–397.

14. Hankey GJ. Secondary prevention of ischemic stroke. Lancet Neurol. 2014;13(2):178–194.

15. Johnston SC, Amarenco P, Denison H, et al. Ticagrelor and aspirin in acute ischemic stroke. N Engl J Med. 2020;383:207–217.