TIZIMLI SKLERODERMIYA: PATOGENEZ, KLINIK KECHISH, DIAGNOSTIKA VA DAVOLASHNING ZAMONAVIY YONDASHUVLARI
Keywords:
tizimli sklerodermiya, tizimli skleroz, Raynaud fenomeni, interstitsial o‘pka kasalligi, autoantitanachalar, kapillyaroskopiya, antifibrotik terapiya, immunosupressiya.Abstract
Tizimli sklerodermiya, ya’ni tizimli skleroz, kam uchraydigan, ammo ko‘p a’zoli shikastlanish bilan kechadigan autoimmun biriktiruvchi to‘qima kasalligidir. Kasallikning markazida uchta yirik patobiologik halqa – immun tizimining disbalansi, mikrotomirlar zararlanishi va fibroblastlar faolligining oshishi natijasida kollagenning ortiqcha to‘planishi turadi.
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