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Keywords

MRONJ, jag‘ osteonekrozi, so‘lak biomarkerlari, MMP9, hypotaurine, proteomika, metabolomika,

How to Cite

DORI VOSITALARI BILAN BOG‘LIQ JAG‘ SUYAKLARI OSTEONEKROZINI (MRONJ) ERTA ANIQLASHDA SO‘LAK BIOMARKERLARINING DIAGNOSTIK AHAMIYATI . (2026). "XXI ASRDA INNOVATSION TEXNOLOGIYALAR, FAN VA TAʼLIM TARAQQIYOTIDAGI DOLZARB MUAMMOLAR" Nomli Respublika Ilmiy-Amaliy Konferensiyasi, 4(9), 143-151. https://universalpublishings.com/index.php/itfttdm/article/view/20727

Abstract

Maqolada dori vositalari bilan bog‘liq jag‘ suyaklari osteonekrozini  (medication-related osteonecrosis of the jaw, MRONJ) erta aniqlashda so‘lak  biomarkerlarining diagnostik ahamiyati zamonaviy dalillar asosida baholandi.  Tadqiqot birlamchi klinik tajriba emas, balki sistematik sharhlar, metabolomik va  proteomik case-control tadqiqotlar, AAOMS va MASCC/ISOO klinik hujjatlari hamda  O‘zbekiston stomatologik adabiyotlariga tayangan ikkilamchi dalillar sintezidi

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References

1. Ruggiero, S. L., Dodson, T. B., Aghaloo, T., Carlson, E. R., & Ward, B. B. (2022). American Association of Oral and Maxillofacial Surgeons’ position paper on medication-related osteonecrosis of the jaws—2022 update. Journal of Oral and Maxillofacial Surgery, 80(5), 920–943.

2. Yarom, N., Abdalla-Aslan, R., Migliorati, C., et al. (2025). MASCC/ISOO Clinical Practice Statement: Imaging and clinical laboratory tests in the diagnosis and management of medication-related osteonecrosis of the jaw. Supportive Care in Cancer, 33, 852.

3. Are medication-induced salivary changes the culprit of osteonecrosis of the jaw? A systematic review. (2023). Frontiers in Medicine, 10, 1164051. https://doi.org/10.3389/fmed.2023.1164051

4. Lorenzo-Pouso, A. I., Bravo, S. B., Carballo, J., del Chantada-Vázquez, M. P., Bagán, J., Bagán, L., Chamorro-Petronacci, C. M., Conde-Amboage, M., López López, R., García-García, A., & Pérez-Sayáns, M. (2023). Quantitative proteomics in medication-related osteonecrosis of the jaw: A proof-of-concept study. Oral Diseases, 29, 2117–2129. https://doi.org/10.1111/odi.14201

5. Yatsuoka, W., et al. (2019). Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw. PLoS ONE / related indexed publication. PMID: 31404085

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