Keywords
genetik markerlar,
polimorfizm,
TLR4,
CXCR1,
How to Cite
Abstract
Qaytalanuvchi siydik yo‘llari infeksiyalari (QSYI) bolalarda uchraydigan eng dolzarb infeksion kasalliklardan biri bo‘lib, uning tez-tez qaytalanishi buyrak parenximasining shikastlanishi, arterial gipertenziya va surunkali buyrak kasalligi rivojlanishiga sabab bo‘lishi mumkin. So‘nggi yillarda molekulyar genetika sohasidagi yutuqlar infeksiyaga moyillikni baholashda immun javob genlari polimorfizmlaridan foydalanish imkoniyatlarini kengaytirdi. TLR4, TLR2, IL-8, CXCR1 va TGF-β genlari qaytalanuvchi infeksiyalarga moyillik bilan bog‘liq eng muhim genetik markerlar sifatida e'tirof etilmoqda. Genetik markerlarni klinik va laborator ko‘rsatkichlar bilan birgalikda baholash yuqori xavf guruhidagi bolalarni erta aniqlash hamda shaxsiylashtirilgan profilaktika va davolash strategiyalarini ishlab chiqishda muhim ahamiyatga ega.
References
1. Yu J, Pereira GMV, Allen-Brady K, et al. Genetic polymorphisms associated with urinary tract infection in children and adults: a systematic review and meta-analysis. Am J Obstet Gynecol. 2024;230(6):600–609.e3.
2. Isali I, Wong TR, Batur AF, et al. Recurrent urinary tract infection genetic risk: a systematic review and gene network analysis. Int Urogynecol J. 2024;35(2):259–271.
3. Aksu B, Afonso AC, Akil I, et al. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: The UTILISE Study. Pediatr Nephrol. 2024;39(2):483–491.
4. Sav NM, Eroz R, Kalay DN, et al. Investigation of TLR4 Polymorphism in Children with Vesicoureteral Reflux and Renal Scarring. Balkan J Med Genet. 2024.
5. Gkiourtzis N, Stoimeni A, Glava A, et al. Prophylaxis Options in Children With a History of Recurrent Urinary Tract Infections: A Systematic Review. Pediatrics. 2024
