Ключевые слова
Как цитировать
Аннотация
Polycystic ovary syndrome is a common endocrine disease in women, characterized by heterogeneous presentation of hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology. This study was carried out to assess plasma levels of testosterone, estradiol calcium and cholesterol levels among females with polycystic ovarian syndrome (PCOs).
Forty females aged 18-35 years diagnosed by ultrasonography and Anti-Müllerian hormone (AMH) test in Alsir Abu-Hassan
center for fertility in Khartoum State, and forty apparently healthy individuals as control group participated in this study.
Plasma testosterone and estradiol measured by using ELISA, cholesterol measured by BS-380 chemistry analyzer, and calcium by colorimetric method. Results were analyzed using statistical package for social science (SPSS), computer programmed version 21. The study showed that, the mean plasma levels of testosterone and T/E2 ratio were significantly increased in PCOs female patients. For testosterone (1.4±1.1 versus 0.87±0.65ng/ml, p-Value =0.011). For T/E2 ratio (0.019±0.015 versus 0.01±0.008 ng/pg,p-Value =0.022). Also the finding of this study showed insignificant difference in estradiol levels between PCOs compared with control group. (Mean±SD: 86±39versus 101±38.6 pg/ml) respectively with P. Value 0.086. The mean plasma levels of cholesterol was significantly increased in PCOs female patients. (Mean±SD: 207.6±33.4 versus112±33.4 mmoL /L) respectively with P.vale 0.000. The mean level of plasma calcium was significantly decreased (p.value 0.000). It is concluded that: the plasma levels of testosterone, T/E2 ratio and cholesterol are higher in PCOs female patients, while calcium level decreased.
Библиографические ссылки
Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertilityand Sterility. 2016;106(1):6– 15
Simon Walker, Geoffrey Beckett, Pater Rae, Peter Ashby. (Ed.) (2013).WHITBY'S CLINICAL BIOCHEMISTRY Lecture Notes. 9Th editions. UK. John Wiley &Sons. 141- 147.
Tayrab, E., Ali ,M., Modawe, G.A., Naway, L(2014). Serum Anti-Müllerian hormone as laboratory predictor in infertile women with and without polycystic ovary syndrome. 2(3):61-6.
William J Marshall, Stephen K, Bangert Marta Lapsley.
(2012). Clinical chemistry, seventh edition. China. Elsevier.258-272.
Lergo ,R., Kunselman, A., Dunaif, A(2001).Prevelence and predictors of dyslipidaemia in women with polycystic ovary syndrome, Am JMed., 111: 607-613.
Johnstone ,E. Rosen, M.Neril ,R.Trevithick, D.Sternfeld, B.Murphy, R(2010)The polycystic ovary post-rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance. endocrinol metab.;95(11):4965-72.
Madhu, L.Vijay Bhaskar, S. Sharma, A. Sumapreethi.(2012). Marker of oxidative stress and serum lipid in PCOS ,journal of evaluation of medical and dental science .vol 1.P.769.
Belinda George and M Ganapathi Bantwal. (2016). Polycystic Ovary Syndrome (PCOS) - From in Utero to Menopause. Diabetes & Obesity International Journal. 1(2).107.
Shang-Gwo Horng, Tzu-Hao Wang, Hsin-Shih Wang.
(2008).Estradiol-to-Testosterone Ratio Is Associated with Response to Metformin Treatment in Women with Clomiphene Citrate- Resistant Polycystic Ovary Syndrome (PCOS). Chang Gung MedJ .31. 477-83.
Elisabeth Lerchbaum1,2*, Verena Schwetz1 , Thomas Rabe2 , Albrecht Giuliani3 , Barbara ObermayerPietsch( 2014). Hyperandrogenemia in Polycystic Ovary Syndrome: Exploration of the Role of Free Testosterone and Androstenedione in Metabolic Phenotype. PLOS ONE; 9 (10). 1 - 12.
Adel F., Begawy. , Akmal, N., El-Mazny. , Nermeen A., Abou-Salem. , Nagwa, E and. El-Taweel. (2010). Anti- Mu¨ llerian hormone in polycystic ovary syndrome and Norma-ovulatory women: Correlation with clinical, hormonal and Ultrasonographic parameters. Middle East Fertility Society Journal. (15).253-258.
Al-Hakeem H K, Kadhem M A. (2009). Is lipid profile in women with polycystic ovary syndrome related to serum calcium or magnesium? Journal of Karbala University; 7(2):48-53
Laven J S, Mulders A G, Visser J A, Themmen A P et al
(2004). Anti-Mullerian hormone serum concentrations in normoovulatory and an ovulatory women of reproductive age. J Clin Endocrinol Metab; 89:318-323.
Valkenburg ,O., Steegers-Theunissen, R.P., Smedts,H.P., Dallinga-Thie ,G.M., Fauser ,B.C., Westervel,E.H ( 2008).A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: A case-control study. J clin endocrinol metab;93:470-6.
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.