Keywords
How to Cite
Abstract
Maqolada kolxamin (demekolsin, demecolcine) asosida 2-metil-5-etilpiridin fragmentini tutuvchi yangi N-substitutsiyalangan hosilani olishning ilmiy asoslangan sintez strategiyasi taklif etildi. Adabiyotlar tahlili kolxaminning C₂₁H₂₅NO₅ formulali ikkilamchi amin ekanini, 2-metil-5-etilpiridin esa C₈H₁₁N formulali alkilpiridin ekanini ko‘rsatadi. Mazkur ikki asosning to‘g‘ridan-to‘g‘ri aralashishi barqaror kovalent hosila berishi uchun yetarli reaktivlikka ega emas; shu sababli 2-metil 5-etilpiridinning metil guruhini avval 5-etil-2-(xlorometil)piridin ko‘rinishiga funksionallashtirish, keyin esa kolxaminning ikkilamchi amin markazida N-alkillash taklif qilindi. Hisoblangan maqsadli mahsulot formulasi C₂₉H₃₄N₂O₅, o‘rtacha molyar massasi 490,60 g/mol va hisoblangan [M+H]⁺ qiymati m/z 491,2540 ni tashkil etadi.
References
1. National Center for Biotechnology Information. (2026). PubChem Compound Summary for CID 220401, Demecolcine. PubChem.
2. Moioli, E., Schmid, L., Wasserscheid, P., & Freund, H. (2017). A new reaction route for the synthesis of 2-methyl-5-ethylpyridine. Reaction Chemistry & Engineering, 2, 754–762. https://doi.org/10.1039/C7RE00100B
3. Moioli, E., Schmid, L., Wasserscheid, P., & Freund, H. (2021). Kinetic modelling of reactions for the synthesis of 2-methyl-5-ethyl pyridine. Reaction Chemistry & Engineering, 6, 1254–1265. https://doi.org/10.1039/D1RE00085C
4. Chen, B., Liu, X., Hu, Y.-J., Zhang, D.-M., Deng, L., Lu, J., Min, L., Ye, W.-C., & Li, C.-C. (2017). Enantioselective total synthesis of (−)-colchicine, (+)-demecolcinone and metacolchicine: Determination of the absolute configurations of the latter two alkaloids. Chemical
Science, 8, 4961–4966. https://doi.org/10.1039/C7SC01341H
5. Nett, R. S., et al. (2021). Discovery and engineering of colchicine alkaloid biosynthesis. Nature, 584/related open-access version.
This work is licensed under a Creative Commons Attribution 4.0 International License.
