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Abstract
Atherosclerosis is a chronic inflammatory disease of medium and large arteries in which lipids, immune cells and connective tissue accumulate within the arterial wall. Its development is gradual, beginning with endothelial dysfunction and retention of cholesterol-containing lipoproteins, followed by the formation of fatty streaks and more complex fibrous plaques. Some plaques remain relatively stable, while others develop a large lipid-rich necrotic core and a weakened fibrous cap.
References
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