ONKOGEN VIRUSLAR VA DIAGNOSTIK TEKSHIRUVLAR
Keywords:
onkogen viruslar, onkoviruslar, inson papilloma virusi (HPV), gepatit B virusi (HBV), gepatit C virusi (HCV), Epstein-Barr virusi (EBV), Kaposi sarkomasi gerpes virusi (KSHV/HHV-8), HTLV-1, Merkel hujayra poliomavirusi (MCPyV), virusli onkogenez, saraton etiologiyasi, molekulyar diagnostika, real vaqt PCR, NGS sekvenslash, serologik testlar, HPV DNK testi, virus integratsiyasi, skrining dasturlari, vaksinoprofilaktika, O‘zbekiston epidemiologiyasi.Abstract
Onkogen viruslar (onkoviruslar) inson saratonining global yuklamasining muhim qismini — taxminan 12–20% ini tashkil etuvchi oldini olish mumkin bo‘lgan etiologik omillar hisoblanadi. Jahon Sog‘liqni Saqlash Tashkiloti (JSST) va Xalqaro Saraton Tadqiqotlari Agentligi (IARC) ma’lumotlariga ko‘ra, 2025-yil holatiga kelib inson uchun kanserogen sifatida tasniflangan yetti ta asosiy virus mavjud: inson papilloma virusi (HPV, yuqori xavfli tiplar), gepatit B virusi (HBV), gepatit C virusi (HCV), Epstein-Barr virusi (EBV), Kaposi sarkomasi bilan bog‘liq gerpes virusi (KSHV/HHV-8), inson T-limfotrop virusi tip 1 (HTLV-1) va Merkel hujayra poliomavirusi (MCPyV).
References
1.International Agency for Research on Cancer (IARC). (2025). IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Report of the Advisory Group to Recommend Priorities for the IARC Monographs during 2025–2029. Lyon: IARC. https://monographs.iarc.who.int/wp-content/uploads/2024/11/AGP_Report_2025-2029.pdf
2.Xiao Q, et al. (2025). Viral oncogenesis in cancer: from mechanisms to therapeutics. Signal Transduction and Targeted Therapy, 10: Article number (open access). https://doi.org/10.1038/s41392-025-02197-9
da Silva Torres MK, et al. (2025). The Impact of Oncogenic Viruses on Cancer Development. PMC, Article PMC12292244. https://pmc.ncbi.nlm.nih.gov/articles/PMC12292244/
3.Galati L, et al. (2024). Human Oncogenic Viruses: Characteristics and Prevention. PMC, Article PMC10974567. https://pmc.ncbi.nlm.nih.gov/articles/PMC10974567/
World Health Organization (WHO). (2023–2025). Global Cancer Observatory (GLOBOCAN) and Infection-Attributable Cancers Data. Lyon: IARC/WHO. https://gco.iarc.who.int/
de Martel C, et al. (2020, updated references in 2025 reports). Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis. The Lancet Global 4.Health (with updates in IARC 2025 reports).
Oltieva MP, et al. (2025). Epidemiology of high-risk HPV in Uzbekistan among 44000 women – genotypes, risk profiles and screening needs. PMC, Article PMC12709833. https://pmc.ncbi.nlm.nih.gov/articles/PMC12709833/
5.Sharipova IP, et al. (2024). Prevalence of high-risk human papillomavirus genotypes among women in Uzbekistan, 2021–2023. Journal of Gynecologic Oncology, 36: e7. https://doi.org/10.3802/jgo.2025.36.e7
6.ICO/IARC Information Centre on HPV and Cancer. (2023). Uzbekistan: Human Papillomavirus and Related Cancers, Fact Sheet 2023. https://hpvcentre.net/statistics/reports/UZB_FS.pdf
7.Ussai S, et al. (2025). Cervical cancer in Eastern Europe and Central Asia: the first signs of progress? The Lancet Regional Health – Europe. https://doi.org/10.1016/j.lanepe.2025.00059-7
8.Ng CS. (2025). Immunotherapy of Oncovirus-Induced Cancers: A Review on the Development and Efficacy of Targeted Vaccines. Vaccines, 13(9): 911. https://doi.org/10.3390/vaccines13090911
9.Wu P, et al. (2023, with 2025 updates). Oncogenic virus integration: Moving toward clinical applications. MedComm – Future Medicine. https://doi.org/10.1002/mef2.1393 (updated references in recent reviews).
