IMMUNOINFLAMMATORY FACTORS AS PREDICTORS OF ISCHEMIC HEART DISEASE DEVELOPMENT IN PATIENTS WITH ARTERIAL HYPERTENSION
Keywords:
arterial hypertension, ischemic heart disease, subclinical myocardial injury, high-sensitivity troponin, immunoinflammation, cytokines, complement.Abstract
The article presents the results of a study on clinical, laboratory, and immunoinflammatory characteristics in patients with arterial hypertension (AH) and in those with combined pathology of AH and ischemic heart disease (IHD). A total of 78 patients were examined and divided into two groups: patients with isolated AH (Group I) and patients with AH complicated by IHD (Group II). The control group consisted of conditionally healthy individuals.
References
1. Stougiannou TM et al. Stem cell mechanisms in ischemic heart disease and myocardial repair // Biology. – 2024.
2. Tehrani DM et al. High-sensitivity troponin and cardiovascular risk prediction // Journal of the American College of Cardiology. – 2023–2025.
3. Libby P. Inflammation in atherosclerosis: from pathophysiology to practice // Journal of the American College of Cardiology. – 2021.
4. Ridker PM et al. Anti-inflammatory therapy and cardiovascular risk reduction: IL-6 pathway insights // New England Journal of Medicine. – 2020.
5. Bujak M., Frangogiannis NG The role of TGF-β signaling in myocardial remodeling and fibrosis // Cardiovascular Research. – 2020.
6. Ferrara N. VEGF and regulation of angiogenesis in ischemic conditions // Nature Reviews Cardiology. – 2020.
7. Boc V., Blinc A., Boc A. The role of high-sensitivity cardiac troponin and ischemia-modified albumin in cardiovascular diseases // International Journal of Molecular Sciences. – 2025. – Vol. 26(22). – P. 11214.
8. Liu X. et al. Global burden of hypertensive heart disease and ischemic heart disease: trends and projections // Global Health Research and Policy. – 2025.
9. Li T. et al. Extracellular vesicles and their role in cardiovascular diseases // Frontiers in Cardiovascular Medicine. – 2025.









