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Abstract
Наибольшие изменения выявлялись у новорожденных с ГИЭ тяжелой
степени, характеризовавшиеся значительным повышением уровня
глутаминовой кислоты, аланина, серина, глицина, пролина, тогда как
содержание аспарагиновой кислоты, гистидина, глутамина, валина и
фенилаланина не изменилось по сравнению с показателями при легкой
степени ГИЭ. Аминокислотный состав СМЖ изучен у 90 недоношенных
детей с ГИЭ разной степени тяжести
References
1. Володин Н. Н. Перинатальная неврология — проблемы и пути решения.//Журн. неврологии и психиатрии им. С.С. Корсакова. – 2009. Т. 10. – С.4—8.
2. Барашнев Ю.И. Перинатальная неврология. - М.: Триада-Х, 2001. – 640 с.
3. Барашнев Ю.И. Гипоксическая энцефалопатия: гипотезы патогенеза
церебральных расстройств и поиск методов лекарственной терапии// Российский вестник перинатологии и педиатрии. - 2002. - № 1. – С. 6-8.
4. Miller R., Keshen T., Jahoor F. Compartmentation of endogenous synthesized
amino acids in neonates// J. Surg. Res. -1996. – V. 65 (1). – P. 199-203.
5. The glutamate-glutamine cycle as an inducible, protective face of macrophage
activation/ Gras G., Porcheray F., Samah B., Leone C. //J Leukoc Biol. – 2006. – V. 80 (5). - 1067-1075.
6. D-serine is an endogenous ligand for the glycine site of the N-methyl-Daspartate receptor/ Mothet J.P., Parent A.T., Wolosker H. et al.// Proc. Natl. Acad. Sci U S A. – 2000. – V. 97 (9). – P. 4926-4931.
7. Wolosker H., Panizzutti R., De Miranda //J. Neurobiology through the lookingglass:D-serine as a new glial-derived transmitter. Neurochem Int. – 2002. – V. 41 (5). –P. 327-332.
8. Glutamate reduces secretion of l-serine in astrocytes isolated from stroke-prone
spontaneously hypertensive rats/ Yamagata K., Shoji Y., Terashima T., Yokogoshi H. //Neuroscience. – 2006. – V. 143 (3). – P. 729-737.
9. Hong-Ping G., Bao-Shan K.U. Neuroprotective effect of L-lysine
monohydrochloride on acute iterative anoxia in rats with quantitative analysis of
electrocorticogram// Life Sci.- 1999. – V. 65 (2). - PL19-PL25.
10. Mattson M.P. Excitotoxic and excitoprotective mechanisms: abundant targets
for the prevention and treatment of neurodegenerative disorders//Neuromolecular Med. –2003. – V. 3. – P. 65-94.
11. Hazell A.S. Excitotoxic mechanisms in stroke: an update of concepts and
treatment strategies// Neurochem Int. – 2007. – V. 50. – P. 941-953.
12. Lee J., Duan W., Mattson M.P. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.//J Neurochem. – 2002. – V. 82. –P. 1367-1375.
13. Wood A.M, Bristow D.R. N-methyl-D-aspartate receptor desensitisation is
neuroprotective by inhibiting glutamate-induced apoptotic-like death.//J Neurochem. –1998. – V. 70 (2). – P. 677-687.
14. Bazan-Peregrino M., Gutierrez-Kobeh L., Moran J. Role of brain-derived
neurotrophic factor in the protective action of N-methyl-D-aspartate in the apoptotic death of cerebellar granule neurons induced by low potassium.//J Neurosci Res. -2007. –V. 85 (2). – P. 332-341.
15. Brain-derived neurotrophic factor is induced as an immediate early gene
following N-methyl-D-aspartate receptor activation/Hughes P., Beilharz E., Gluckman P.,Dragunow M.// Neuroscience. – 1993. – V. 57 (2). – P. 319-328.
16. Glutamate reduces secretion of l-serine in astrocytes isolated from strokeprone spontaneously hypertensive rats/ Yamagata K., Shoji Y., Terashima T., Yokogoshi H. // Neuroscience. – 2006. – V. 143 (3). – P. 729-737.
17. Saransaari P., Oja S.S. Beta-alanine release from the adult and developing
hippocampus is enhanced by ionotropic glutamate receptor agonists and cell-damaging conditions//Neurochem Res. – 1999. – V. 24 (3). – P. 407-414.
18. Alanine: Glutamate ratios as an index of reversibility of cerebral ischemia in
gerbils/ Conger K.A., Garcia J.H., Kauffman F.C. et al. // Exp. Neurol. – 1981. – V. 71(2). – P. 370-382.
19. Wood A.M, Bristow D.R. N-methyl-D-aspartate receptor desensitisation is
neuroprotective by inhibiting glutamate-induced apoptotic-like death.//J Neurochem. –1998. – V. 70 (2). – P. 677-687.
20. Bazan-Peregrino M., Gutierrez-Kobeh L., Moran J. Role of brain-derived
neurotrophic factor in the protective action of N-methyl-D-aspartate in the apoptotic death of cerebellar granule neurons induced by low potassium//J Neurosci Res. – 2007. –V. 85 (2). – P. 332-341.
21. Brain-derived neurotrophic factor is induced as an immediate early gene
following N-methyl-D-aspartate receptor activation/Hughes P., Beilharz E., Gluckman P.,Dragunow M.// Neuroscience. – 1993. - V. 57 (2). – P. 319-328.
22. Mattson M.P. Calcium and free radicals: mediators of neurotrophic factor and
excitatory transmitter-regulated developmental plasticity and cell death//Perspect Dev.Neurobiol. – 1996. – V. 3. – P. 79-91.
23. Suzuki M. et al. Glutamate enhances proliferation and neurogenesis in human
neural progenitor cell cultures derived from the fetal cortex// Eur J Neurosci. – 2006. – V.24. – P. 645-653.
24. Marini A.M. et al. Activity-dependent release of brain-derived neurotrophic
factor underlies the neuroprotective effect of N-methyl-D-aspartate//J Biol Chem. – 1998.– V. 273. – P. 29394-29399.
25. Lee J., Duan W., Mattson M.P. Evidence that brain-derived neurotrophic
factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice//J Neurochem. – 2002. – V. 82. – P. 1367-1375.
26. Mattson M.P. Glutamate and neurotrophic factors in neuronal plasticity and disease//Ann N Y Acad Sci. – 2008. V. 1144. – P. 97-112.
27. Jean Y.Y., Lercher L.D., Dreyfus C.F. Glutamate elicits release of BDNF from basal forebrain astrocytes in a process dependent on metabotropic receptors and the PLC pathway// Neuron Glia Biol. – 2008. – V. 4 (1). – P. 35-42.