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Abstract
The presented analytical review of literature addresses the state of the study of the morphology of microglia, astrocytes, oligodendrocytes, and the blood-brain barrier in suicide. According to the generalized data, the most characteristic localization of changes in the development of suicidal behavior was determined by the suture nucleus, prefrontal and anterior cingulate cortex. There is evidence of a correlation between the development of suicidal behavior and an increase in inflammatory cytokines in the prefrontal cortex, disruption of the connection between astrocytes and oligodendrocytes in the anterior cingulate cortex, as well as indication of involvement in the process of forming suicidal behavior of the cortex, striatum, preclinium and cuneiform, orbitofrontal cortex.
References
1. Chesney E., Goodwin G.M., Fazel S. Risks of all-cause and suicide mortality in mental disorders: A meta-review // World Psychiatry. World Psychiatric Association, 2014.Vol. 13, N 2. P. 153–160.
2. Vahid-Ansari F., Albert P.R.Rewiring of the serotonin system in major depression // Front Psychiatry. 2021. N 12.
3. Lutz P.E., Mechawar N.,Turecki G.Neuropathology of suicide: Recent findings and future directions // Mol Psychiatry. 2017. Vol. 22, N 10.P. 1395–1412.
4. Ginhoux F., Prinz M. Origin of microglia: current concepts and past controversies // Cold Spring Harb Perspect Biol. 2015. Vol. 7
5. Butovsky O., Siddiqui S., Gabriely G., et al. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS // J Clin Invest. 2012. Vol. 122, N 9. P. 3063–3083.
6. Rangaraju S., Raza S.A., Li NX., et al. Differential phagocytic properties of CD45low microglia and CD45high brain mononuclear phagocytes-activation and age-related effects // Front Immunol. 2018. N 9.
7. Courtet P., Giner L., Seneque M., et al. Neuroinflammation in suicide: toward a comprehensive model // World J Biol Psychiatry. 2016. Vol. 17, N P. 564–586.
8. Mccarty M.F., Lerner A. Expert review of neurotherapeutics the second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation // Expert Rev Neurother. 2021. Vol. 21,N 5. P. 559–570.
9. Steiner J., Walter M., Gos T., et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission ? //J.Neuroinflammation. 2011. N 8. P. 94.
10. Baharikhoob P., Kolla N.J. Microglial dysregulation and suicidality: A stress-diathesis perspective // Front Psychiatry. 2020. N 11. P.781.
11. Brisch R.,Steiner J., Mawrin C., et al. Microglia in the dorsal raphenucleus plays a potential role in both suicide facilitation and prevention in affective disorders // Eur Arch Psychiatry Clin Neurosci.2017. Vol. 267, N 5. P. 403–415.