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Abstract
Ko‘kyo‘tal (pertussis) va parako‘kyo‘tal kasalliklar respirator yo‘llarning yuqori darajada yuquvchan bakterial infeksiyalaridan bo‘lib, ularning etiologiyasi va patogenezi klinik va epidemiologik jihatdan o‘rganishga katta ehtiyoj tug‘diradi. Ushbu maqolada Bordetella pertussis va Bordetella parapertussis bakteriyalarining molekulyar-genetik xususiyatlari, ularning virulensiya omillari va inson organizmidagi patofiziologik ta'sirlari batafsil tahlil qilingan. Tadqiqotda, shuningdek, kasalliklarni keltirib chiqaruvchi asosiy toksinlar — pertussis toksini, adenilat siklaza, trakeal toksin va boshqa oqsillar ta'siri, immun tizimining javobi hamda kasallikning o‘ziga xos klinik ko‘rinishlari asosida tibbiy diagnostika va davolash protokollari muhokama qilingan. Maqolada, shuningdek, ko‘kyo‘tal va parako‘kyo‘talning epidemiologik tendensiyalari, vaksinalar samaradorligi va profilaktika choralari ham keng qamrovda ko‘rib chiqilgan. Yuqori darajadagi vaksinalar va samarali immunoprofilaktika usullarining ahamiyati, shuningdek, yangi molekulyar diagnostika vositalarining rivojlanishi hamda antimikrobiyal terapiya strategiyalari tibbiyot amaliyotidagi dolzarb masalalar sifatida taqdim etilgan.
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