Abstract
Qondagi shaklli elementlar o‘rtasidagi o‘zaro ta’sirda gumoral omillarning rolini tushuntiruvchi ushbu maqola sitokinlar, komplement tizimi, akut faza oqsillari va boshqa mediatorlarning mexanizmlarini ko‘rib chiqadi. Metodik bo‘limda zamonaviy analiz usullari, natijalar bo‘limida laborator tadqiqotlar va klinik tadqiqotlardan olingan ma’lumotlar taqdim etiladi. Xulosa qismida topilmalar umumlashtirilib, istiqbolli tadqiqot yo‘nalishlari belgilanadi.
References
1. Sproston NR, Ashworth JJ. Humoral Innate Immunity and Acute-Phase Proteins. Int J Mol Sci. 2022;23(8):3859.
2. D’Alessandro A, Zolla L. The evolving erythrocyte: RBCs as modulators of innate immunity. Front Immunol. 2018;9:2746.
3. Gabay C, Kushner I. Acute phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448–454.
4. Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785–797.
5. Pai AJ, et al. Crosstalk between Red Blood Cells and the Immune System. J Thromb Haemost. 2019;17(3):382–391.
6. Doolittle RF. Complement proteins: structure, function, and mechanism. Annu Rev Immunol. 2017;35:54–76.
7. Pepys MB, Hirschfield GM. Humoral Innate Immunity and Acute-Phase Proteins. N Engl J Med. 2022;387(10):966–974. 8. Murray PJ, Wynn TA. Macrophage cytokines: involvement in immunity and pathogenesis. Front Immunol. 2014;5:491.
9. Liu X, Chen Y, Zhang Y. Cytokines: from clinical significance to quantification. Adv Sci. 2020;7(24):2004433.
10. Almada P, et al. Complement receptors and their role in leukocyte recruitment. J Immunol. 2021;206(2):358–366.
11. Topping MD, et al. Red blood cells are dynamic reservoirs of cytokines. Sci Rep. 2018;8:8554.
12. Haeggström JZ, Funk CD. Lipid-mediator networks in immunity. Nat Rev Immunol. 2011;11(11):658–670.
13. Lamping N, et al. LPS-binding protein protects mice against endotoxin shock. Nature. 1998;398(6722):390–394.
14. Ricklin D, Lambris JD. Complement-targeted therapeutics. Nat Biotechnol. 2013;31(11):917–926.
15. De Buck M, et al. Innate humoral defense factors. J Immunol. 2013;190(11):6286–6295.

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