Keywords
gastrit,
oshqozon yarasi
patogenez,
ureaza,
How to Cite
Abstract
Ushbu maqola Helicobacter pylori (H. pylori) bakteriyasining oshqozon-ichak trakti kasalliklari patogenezidagi fundamental o‘rnini tahlil qilishga bag‘ishlangan. XX asr oxirida tibbiyot olamida inqilobiy kashfiyot sifatida e’tirof etilgan ushbu gramm-manfiy, spiral shaklidagi bakteriya bugungi kunda surunkali gastrit, oshqozon va o‘n ikki barmoqli ichak yarasi kasalliklarining asosiy etiologik omili hisoblanadi. Maqolada bakteriyaning oshqozon kislotali muhitiga moslashish mexanizmlari, xususan, ureaza fermentini ishlab chiqarish orqali ammiak hosil qilib, o‘z atrofidagi muhitni neytrallash jarayonlari qamrab olinadi. Tadqiqotda H. pylorining sitotoksin ishlab chiqaruvchi shtammlari (CagA va VacA) ta’sirida epiteliy hujayralarining zararlanishi, surunkali yallig‘lanish, shuningdek, atrofik gastrit va oshqozon adenokarsinomasi kabi asoratlar genetik va atrof-muhit omillari kontekstida yoritiladi. Shuningdek, zamonaviy diagnostika usullari va eradikatsiya terapiyasining samaradorligi tahlil qilinadi.
References
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