THE ROLE OF ANTI MULLERIAN HORMONE (AMH) LEVELS AS PREDICTIVE AND DIAGNOSTIC BIOMARKER OF AGE AT MENOPAUSE AMONG INFERTILE SUDANESE WOMEN
Vol. 2 No. 4 (2024), Articles
Vol. 2 No. 4 (2024)

THE ROLE OF ANTI MULLERIAN HORMONE (AMH) LEVELS AS PREDICTIVE AND DIAGNOSTIC BIOMARKER OF AGE AT MENOPAUSE AMONG INFERTILE SUDANESE WOMEN

Articles
Published 2024-04-04
Razaz Yassin Khalafalla abdelrahman
Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
Abubaker Hassan Attaelmawla
Department of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
Adam Dawoud Abakar
Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
Khalid Abdelsamea Mohamedahmed
Department of Hematology and Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
PDF
DOI

Keywords

Sudanese infertile women, AMH, FSH, LH, menopause age.

How to Cite

Razaz Yassin Khalafalla abdelrahman, Abubaker Hassan Attaelmawla, Adam Dawoud Abakar, & Khalid Abdelsamea Mohamedahmed. (2024). THE ROLE OF ANTI MULLERIAN HORMONE (AMH) LEVELS AS PREDICTIVE AND DIAGNOSTIC BIOMARKER OF AGE AT MENOPAUSE AMONG INFERTILE SUDANESE WOMEN. Yangi O’zbekistonda Tabiiy Va Ijtimoiy-Gumanitar Fanlar Respublika Ilmiy Amaliy Konferensiyasi, 2(4), 5–12. Retrieved from https://universalpublishings.com/index.php/gumanitar/article/view/5011
ACM ACS APA ABNT Chicago Harvard IEEE MLA Turabian Vancouver

Download Citation

Endnote/Zotero/Mendeley (RIS) BibTeX

Abstract

Infertility is a global health problem with an increasing incidence rate among Sudanese women. The study aimed to compare serum anti-mullerian hormone (AMH), folic stimulating hormone (FSH) and luteinizing hormone (LH) between primary infertility and secondary infertility. Furthermore, also to study the effect of woman's age on these hormones. The study was carried out in Khartoum State, Sudan during the period from January to March 2017. A cross sectional hospital included 260 infertile women [169 with primary infertility (mean age 32.7 ± 7.26 years) and 91 with secondary infertility (mean age 35.02 ± 6.25 years). Three ml of venous blood were collected in plain container and serum were obtained by centrifugation, all serum samples were analyzed for AMH, FSH and LH concentration using ELISA techniques. The results were showed significant difference in LH andAMH between primary infertility and secondary  infertility  (P value  =  0.017,  0.001 respectively) and insignificant differences in FSH between them  (P value  = 0.606). Furthermore, the serum AMH level decreased in elder ages (P value = 0.000; r = - 0.4564) and increased of FSH level (P value = 0.001; r = - 0.199). In addition, the serum FSH levels increase in elder ages (P value = 0.001: r = -0.2036). In conclusion, the results of this study showed that hormones play a crucial role in diagnosis infertile women and serum AMH concentration has created more promising results to predicting age at menopause.

PDF
DOI

References

- Boivin, J., Bunting, L., Collins, J. A., Nygren, K. G. (2007). International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Human reproduction. 22(10): 2800.

- Ismail, A. A., and Sakr, S. H. (2010). Low-Cost Infertility Management. Current Women's Health Reviews. 6(2): 73-83.

- Pennings, G., de Wert, G., Shenfield, F., Cohen, J., Tarlatzis, B., Devroey, P. ESHRE Task Force on Ethics and Law: Cross-border reproductive care. (2008). Human reproduction. 23(10): 2182-4.

- Satoh, M., Tokoro, M., Ikegami, H., Nagai, K., Sono, Y., Shin, S. W., Nishikawa, S., Saeki, K., Hosoi, Y., Iritani, A., Fukuda, A., Morimoto, Y., Matsumoto, K.. (2009). Proteomic analysis of the mouse ovary in response to two gonadotropins, follicle-stimulating hormone and luteinizing hormone. Journal of Reproduction and Development. 55(3): 316-26.

- Wayne, J. H., Grzywacz, J. G., Carlson, D. S., Kacmar, K. M. (2007). Work-family facilitation: A theoretical explanation and model of primary antecedents and consequences. Human resource management review. 17(1): 63-76.

- Russell, D. L., and Robker, R. L. (2007). Molecular mechanisms of ovulation: co-ordination through the cumulus complex. Human reproduction update. 13(3): 289-312.

- Weenen, C., Laven, J. S., von Bergh, A. R., Cranfield, M., Groome, N. P., Visser, J. A., Kramer, P., Fauser, B. C., Themmen, A. P. (2004). Anti-Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. MHR: Basic science of reproductive medicine. 10(2): 77-83.

- Cook, C. L., Siow, Y., Taylor, S., Fallat, M. E. (2002). Serum müllerian-inhibiting substance levels during normal menstrual cycles. Fertility and Sterility. 73(4): 859-861.

- Visser, J. A., de Jong, F. H., Laven, J. S., Themmen, A. P. (2006). Anti-Mullerian hormone: a new marker for ovarian function. Reproduction. 131(1): 1-9.

- Helal, I. A., Mohammed, Z. S., Muhson, H. D., Ali, E. N. A., Majeed, M. R., Al-fahham, A. A. (2016). Association between female infertility and hormonal imbalance.

- Mokhtar, S., Hassan, H. A., Mahdy, N., Elkhwsky, F., Shehata, G. (2006). Risk factors for primary and secondary female infertility in Alexandria: a hospital-based case-control study. J Med ResInst. 27(4): 255-261.

- Odiba, A. S., Parker, E. J., Chimere, Y. U. (2014). A Comparative Study of the Serum Levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) During Follicular Phase in Secondary and Primary Infertile Women of Reproductive Age. IOSR Journal of Dental and Medical Sciences. 13(1): 66-72.

- Shoaib, O. M., Nourein, I. H., Elbadri, M. A. (2015). A Prospective Study of Hormonal Changes Among Sudanese Women With Infertility. International Journal of Recent Scientific Research. 6(10): 6956-6959.

- Nam, H-K., Rhie, Y. J., Son, C. S., Park, S. H., Lee, K. H. (2012). Factors to predict positive results of gonadotropin releasing hormone stimulation test in girls with suspected precocious puberty. Journal of Korean medical science. 27(2):194- 199.

- Tola, H., Abbas, M., Alhassan, E., Shrif, N., Rida, M. (2018). Assessment of the Role of the Anti-Mullerian Hormone, Luteinizing Hormone/Follicle Stimulating Hormone Ratio in the Diagnosis of Polycystic Ovary Syndrome in Sudanese Women. Open Access Maced J Med Sci. 6(7): 1244- 1247.

- Lee, D. S., Ryoo, N. Y., Lee, S. H., Kim, S., Kim, J. H. (2013). Basal luteinizing hormone and follicular stimulating hormone: is it sufficient for the diagnosis of precocious puberty in girls?. Annals of pediatric endocrinology & metabolism. 18(4): 196.

- Kahu, E. R., Stephens, C., Leach, L., Zepke, N. (2013). The engagement of mature distance students. Higher Education Research & Development. 32(5): 791-804.

- Liu, X. M., Chan, H. C., Ding, G. L., Cai, J., Song, Y., Wang, T. T., Zhang, D.,Chen, H.,Yu, M. K., Wu, Y. T., Qu, F.,Liu, Y.,Lu, Y. C.,Adashi, E. Y.,Sheng, J. Z.,Huang, H. F. (2015). FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway. Aging cell. 14(3): 409-420.

- Mustafa, A. A. E., Nabag, W. O. M., Elhassan, E. A. (2017). Correlation of Anti Mullerian Hormone (AMH) Level with Clinical & Pituitary Hormones (FSH, LH) in Infertile Sudanese Women with PCOA Case Control Study. AASCIT Journal of Medicine. 3(2): 10-14.

- de Vet, A., Laven, J. S., de Jong, F. H., Themmen, A. P., Fauser, B. C. (2002). Antimüllerian hormone serum levels: a putative marker for ovarian aging. Fertility and Sterility. 77(2): 357-362.

- Reuss, M. L., Kline, J., Santos, R., Levin, B., Timor- Tritsch, I. (1996). Age and the ovarian follicle pool assessed with transvaginal ultrasonography. American journal of obstetrics and gynecology. 174(2): 624-627.