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Abstract
Tug‘ma va irsiy buyrak kasalliklari bolalar va o‘smirlarda surunkali buyrak kasalligi (SKD) hamda buyrak yetishmovchiligining muhim sabablaridan hisoblanadi. Ushbu tezisda buyrak va siydik yo‘llarining tug‘ma anomaliyalari (CAKUT), Alport sindromi,
autosom-dominant va autosom-retsessiv polikistoz kasalliklar kabi holatlarda SKD rivojlanish va progressiya xavfini baholash mezonlari tahlil qilindi. Xavfni stratifikatsiya qilishda glomerulyar filtratsiya tezligi (eGFR), albuminuriya/proteinuriya, arterial gipertenziya, takrorlanuvchi siydik yo‘li infeksiyalari, obstruktiv uropatiya, buyrak parenximasi displaziyasi, oilaviy anamnez va genetik variantlar muhim prognostik omillar sifatida ko‘rib chiqildi.
References
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