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Abstract
Ushbu tezis allergik kasalliklarning kelib chiqishida asosiy rol o'ynaydigan immunologik mexanizmlarni tizimli tahli qiladi. Asosiy e'tibor IgE orqali sodir bo'ladigan I tur gipersensitivlik reaksiyasiga qaratilgan bo'lib, unda antigen (allergen) bilan birinchi marta tanishgandan so'ng organizmda IgE sinfiga mansub antitelolar ishlab chiqarilishi va ularning mast hujayralari va bazofillarga birikishi jarayoni o'rganiladi. Allergik kasalliklarni tushunish va samarali oldini olish uchun ularning immunopatogenezini chuqur bilish zarurligi ta'kidlanadi.
References
1. Abbas, A.K., Lichtman, A.H., & Pillai, S. (2017). Cellular and Molecular Immunology (9th ed.). Elsevier. (Allergiya immunologiyasining asosiy tamoyillari).
2. Galli, S. J., & Tsai, M. (2012). IgE and mast cells in allergic disease. Nature Medicine, 18(5), 693–704.
3. Kay, A. B. (2001). Allergy and allergic diseases. First of two parts. England Journal of Medicine, 344(1), 30-37. (Allergik kasalliklarning umumiy ko'rinishi).
4. Strachan, D.P. (1989). Hay fever, hygiene, and household size. BMJ, 299(6710), 1259-
1260. ("Gigiena gipotezasi" ning klassik asari).
5. Jutel, M., Agache, I., Bonini, S., Burks, A. W., Calderon, M., Canonica, W., ... & Pfaar, O. (2017). International consensus on allergy immunotherapy. Journal of Allergy and Clinical Immunology, 140(4), 950-958.
6. Global Initiative for Asthma (GINA). (2022). Global Strategy for Asthma Management and Prevention.
7. World Allergy Organization (WAO). White Book on Allergy.