How to Cite
Abstract
Multisystemic atherosclerosis simultaneously affecting the carotid and lower extremity peripheral arterial beds represents an aggressive phenotype of macrovascular disease. While macroscopic arterial narrowing is routinely evaluated using anatomical
imaging, systemic endothelial dysfunction often leads to microvascular failure long before structural occlusion completes. Cerebral autoregulation (CA) and cerebrovascular reactivity (CVR) are vital physiological mechanisms maintaining steady cerebral blood flow despite systemic blood pressure fluctuations.
References
1. Aboyans, V., Ricco, J. B., & Bartelink, M. E. (2018). ESC Guidelines on the diagnosis and treatment of peripheral arterial diseases, in collaboration with the European Society for Vascular Surgery (ESVS). European Heart Journal, 39(9), 763-816.
2. Claassen, J. A., Meel-van den Abeelen, A. S., & Simpson, D. M. (2016). Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network. Journal of Cerebral Blood Flow & Metabolism, 36(4), 665-680.
3. Criqui, M. H., & Aboyans, V. (2015). Epidemiology of peripheral artery disease. Circulation Research, 116(9), 1509-1526. Panerai, R. B. (2019). Transcranial Doppler assessment of cerebral autoregulation: Intermittent versus continuous methods. Journal of Neuroimaging, 29(2), 155-168.
4. Formaggia, L., Quarteroni, A., & Veneziani, A. (2009). Cardiovascular Mathematics: Modeling and simulation of the circulatory system. Springer Science & Business Media, Vol. 1.
5. Immink, R. V., van den Born, B. J., & van Montfrans, G. A. (2020). Impaired cerebral autoregulation in patients with malignant hypertension and advanced systemic atherosclerosis. Journal of Hypertension, 38(6), 1104-1112.
