IMMUNITY AND INFECTIOUS DISEASES: THE EXPERIENCE OF COVID-19
Keywords:
SARS-CoV-2, COVID-19, innate immunity, adaptive immunityAbstract
This thesis provides a comprehensive analysis of the complex interplay between the human immune system and SARS-CoV-2, the virus responsible for the COVID-19 pandemic. The central objective is to synthesize the critical immunological lessons learned from this global health crisis, focusing on the dual nature of the immune response: its essential role in viral clearance and recovery, and its potential to cause severe immunopathology. Additionally, it explores the phenomena of waning immunity, viral immune evasion, and the implications of emerging variants. By integrating findings from virology, clinical immunology, and vaccinology, this work concludes that the COVID-19 pandemic has served as a monumental real-world experiment, profoundly advancing our understanding of antiviral immunity and reshaping paradigms for future pandemic preparedness, therapeutic design, and global public health strategy.
References
1. Hu, B., Guo, H., Zhou, P., & Shi, Z. L. (2021). Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology, 19(3), 141–154.
2. Blanco-Melo, D., Nilsson-Payant, B. E., Liu, W. C., Uhl, S., Hoagland, D., Møller, R., ... & Bieniasz, P. D. (2020). Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell, 181(5), 1036-1045.e9.
3. Zhang, Q., Bastard, P., Liu, Z., Le Pen, J., Moncada-Velez, M., Chen, J., ... & Casanova, J. L. (2020). Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science, 370(6515), eabd4570.
4. Grifoni, A., Weiskopf, D., Ramirez, S. I., Mateus, J., Dan, J. M., Moderbacher, C. R., ... & Sette, A. (2020). Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell, 181(7), 1489-1501.e15.
5. Sette, A., & Crotty, S. (2021). Adaptive immunity to SARS-CoV-2 and COVID-19. Cell, 184(4), 861–880.
6. Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., ... & Gruber, W. C. (2020). Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. New England Journal of Medicine, 383(27), 2603-2615.
7. RECOVERY Collaborative Group. (2021). Dexamethasone in Hospitalized Patients with Covid-19. New England Journal of Medicine, 384(8), 693–704.
8. World Health Organization (WHO). (2022). COVID-19 Clinical management: living guideline.
