Keywords
IL-6
TNF-α
polimorfizm
bolalar
How to Cite
Abstract
Qaytalanuvchi siydik yo‘llari infeksiyalari (QSYI) bolalar orasida uchraydigan eng dolzarb bakterial kasalliklardan biri bo‘lib, kasallikning takrorlanishi buyrak parenximasining zararlanishi, chandiqlanish va surunkali buyrak kasalligi rivojlanish xavfini oshiradi. So‘nggi yillarda immunogenetika sohasida olib borilgan tadqiqotlar infeksiyaning qaytalanishida yallig‘lanish jarayonini boshqaruvchi sitokin genlari muhim o‘rin tutishini ko‘rsatmoqda. Ayniqsa, IL-6 va TNF-α genlari polimorfizmlari organizmning immun javob kuchini belgilab, kasallikning og‘irligi hamda qaytalanish xavfiga ta'sir ko‘rsatishi mumkin. Mazkur tezisda ushbu genlar polimorfizmlarining biologik ahamiyati, klinik qo‘llanilishi va prognostik imkoniyatlari zamonaviy ilmiy manbalar asosida tahlil qilinadi.
References
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