ADVANCES IN CARDIOMYOCYTE REGENERATION: FROM MECHANISMS TO CLINICAL PROSPECTS

Kenjaeva Komila Sherzodovna; Tursunmetov Ibodulla Ruzibaevich

Authors

Kenjaeva Komila Sherzodovna Tashkent State Medical University Department of Histology and Medical Biology
Tursunmetov Ibodulla Ruzibaevich Assistant of the Department of Histology and Medical Biology

Keywords:

Cardiomyocyte regeneration, Stem cell–based cardiac therapy, Induced pluripotent stem cells (iPSCs), Myocardial repair, Gene therapy and molecular reprogramming, YAP/TAZ and cell cycle reactivation, Tissue engineering and bioartificial heart patches, 3D bioprinting and biomaterials, Exosome and extracellular vesicle therapy, Nanotechnology in cardiac regeneration, Direct cardiac reprogramming (GMT factors), Fibroblast-to-cardiomyocyte conversion, Cardiac fibrosis reduction, Myocardial infarction recovery, Regenerative medicine and translational cardiology

Abstract

This article discusses the regeneration of cardiomyocytes and highlights recent advances in cardiomyocyte regeneration, focusing on the molecular mechanisms underlying myocardial repair and the translation of these findings into potential therapeutic applications. Particular attention is given to stem cell–based therapies, cellular reprogramming, gene editing technologies, and bioengineering approaches that aim to restore cardiac function following injury.

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