CONGENITAL HEART DISEASES IN NEWBORNS : EARLY DETECTION AND OUTCOMES.
Abstract
- Formation of the primitive heart tube it starts from week 3 of gestation period. It's origin is from splanchnic mesoderm where the two endocardial tube fuse together to form a single primitive heart tube.There are 5 segments which is from cranial to caudal : Truncus arteriosus,bulbus cordis,primitive ventricle,primitive atrium,sinus venosus.If any deviation occurs in these segments it can lead to complex congenital heart disease (CHD).
References
1.Hoffman JIE, Kaplan S.
The incidence of congenital heart disease.
Journal of the American College of Cardiology, 2002;39(12):1890–1900.
→ Classic paper on prevalence and epidemiology.
2.van der Linde D, et al.
Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis.
Journal of the American College of Cardiology, 2011;58(21):2241–2247.
→ Strong global statistics source.
3.Mahle WT, et al.
Role of pulse oximetry in examining newborns for congenital heart disease.
Pediatrics, 2009;124(2):823–836.
→ Important for early screening methods.
4.Thangaratinam S, et al.
Pulse oximetry screening for critical congenital heart defects in newborn infants.
The Lancet, 2012;379(9835):2459–2464.
→ High-impact study on early detection.
5.Donofrio MT, et al.
Diagnosis and treatment of fetal cardiac disease.
Circulation, 2014;129(21):2183–2242.
→ Covers prenatal diagnosis.
6.Kemper AR, et al.
Strategies for implementing screening for critical congenital heart disease.
Pediatrics, 2011;128(5):e1259–e1267.
→ Useful for newborn screening programs.
