MODELING THE ROLE OF HORMONAL DYNAMICS AND ANTI-HORMONAL THERAPIES IN BREAST CANCER: A MULTIMODAL COMPUTATIONAL FRAMEWORK

Dr Saloni Jain; Ayush Sharma; Susheen Bhat; Purvansha

Authors

Dr Saloni Jain Assistant Teacher, Samarkand State Medical University, Uzbekistan
Ayush Sharma Medical Student, Samarkand state Medical University, Uzbekistan
Susheen Bhat Medical Student, Samarkand state medical university, Uzbekistan
Purvansha Medical Student, Samarkand State Medical University, Uzbekistan

Keywords:

Breast cancer; Endocrine therapy; Mathematical modeling; Estrogen receptor; Aromatase inhibitors; Tamoxifen; Treatment resistance; Systems biology; Pharmacokinetics; Computational oncology

Abstract

Breast cancer remains the most prevalent malignancy among women globally, with endocrine therapy representing the cornerstone of treatment for hormone receptor-positive subtypes. However, the emergence of therapeutic resistance poses significant clinical challenges. This narrative review presents a comprehensive computational framework integrating mathematical modeling, systems biology, and clinical pharmacology to understand hormonal dynamics in breast cancer progression and treatment response.

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