ANTI-VIRUS VA ANTIBAKTERIAL MIS-NANO QOPLAMA ISHLAB CHIQARISH: NAZARIY VA AMALIY USULLARI

Normurodova Farzona Ubaydullo qizi; Abdurahmonova Gulzoda Oʻktamovna; Usanova Farzona Beknazar qizi

Authors

Normurodova Farzona Ubaydullo qizi [email protected]
Abdurahmonova Gulzoda Oʻktamovna [email protected]
Usanova Farzona Beknazar qizi Termiz davlat universiteti talabalari

Keywords:

mis nanozarralari, CuO, Cu₂O, nanoqoplama, antibakterial, antivirus, ROS, elektrokimyoviy cho‘ktirish, sol-gel, dezinfeksiya.

Abstract

Maqolada mis asosidagi nanoqoplamalarni (CuNP va CuO/Cu₂O nanozarralari) ishlab chiqarishning ilmiy-texnologik asoslari, sintez metodlari, yuzaga keladigan mexanizmlar va biologik faolligi tahlil qilinadi. Mis nanozarralari bakteriyalar va viruslarga qarshi samarali bo‘lib, ularning ishlash mexanizmi mis ionlari ajralishi, reaktiv kislorod shakllari (ROS) hosil bo‘lishi, hujayra membranasini buzish, oqsillarni denaturatsiya qilish va virus genetik materialini inaktivatsiya qilish kabi jarayonlarga asoslanadi. Shuningdek, maqolada qoplamaning texnologik ko‘rsatkichlari, sintez usullari, biologik samaradorligini baholash metodlari va amaliy qo‘llanish sohalari batafsil yoritiladi.

References

1. ppl. Microbiol., 2018.

2. Grass G., Rensing C., Solioz M., Metallic copper as an antimicrobial surface, Appl. Environ. Microbiol., 2011.

3. Warnes S. L., Keevil C. W., Inactivation of norovirus on copper alloy surfaces, Appl. Environ. Microbiol., 2013.

4. Ren G. et al., Characterisation of copper oxide nanoparticles for antimicrobial applications, Int. J. Antimicrob. Agents, 2009.

5. Borkow G., Gabbay J., Copper, an ancient remedy returning to fight microbial, fungal and viral infections, Curr. Chem. Biol., 2009.

6. Zhang H. et al., Copper-based nanomaterials for antibacterial and antiviral applications, Mater. Sci. Eng. C, 2020.

1. Vincent, M., Hartemann, P., Engels-Deutsch, M. (2018). Contact killing and antimicrobial properties of copper. Journal of Applied Microbiology, 124(4), 1032–1046.

2. Grass, G., Rensing, C., Solioz, M. (2011). Metallic copper as an antimicrobial surface. Applied and Environmental Microbiology, 77(5), 1541–1547.

3. Warnes, S. L., Keevil, C. W. (2013). Inactivation of norovirus on copper alloy surfaces. Applied and Environmental Microbiology, 79(6), 2247–2253.

4. Ren, G., Hu, D., Cheng, E. W. C., Vargas-Reus, M. A., Reip, P., Allaker, R. P. (2009). Characterisation of copper oxide nanoparticles for antimicrobial applications. International Journal of Antimicrobial Agents, 33(6), 587–590.

5. Borkow, G., Gabbay, J. (2009). Copper, an ancient remedy returning to fight microbial, fungal and viral infections. Current Chemical Biology, 3(3), 272–278.

6. Zhang, H., Chen, B., Yang, Y., Xu, T. (2020). Copper-based nanomaterials for antibacterial and antiviral applications. Materials Science and Engineering C, 109, 110576.

7. Santo, C. E., Lam, E. W. N., Elowsky, C. G., Quaranta, D., Domaille, D. W., Chang, C. J., Grass, G., & Turner, R. J. (2011). Bacterial killing by dry metallic copper surfaces. Applied and Environmental Microbiology, 77(3), 794–802.

8. Raffi, M., Mehrwan, S., Bhatti, T. M., Akhter, J. I., Hameed, A., Yawar, W., Hasan, M. (2008). Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli. Annals of Microbiology, 58(1), 75–80.

9. Ren, G., Hu, D., Cheng, E. W., Vargas-Reus, M., Reip, P., Allaker, R. P. (2009). Characterisation of copper oxide nanoparticles for antimicrobial applications. Int. J. Antimicrob. Agents, 33(6), 587–590.