ICHAK MIKROBIOTASI VA INSON SOG‘LIG‘IGA TA’SIRI

Muhammadali Bo’riyev; Orziboni Rabbimova

Authors

Muhammadali Bo’riyev Tibbiy profilaktik fanlar kafedrasi mudiri
Orziboni Rabbimova Termiz iqtisodiyot va servis unversiteti Tibbiyot fakulteti Davolash ishi yo’nalishi

Keywords:

Ichak mikrobiotasi, disbakterioz,, probiotiklar, prebiotiklar, sog‘liqni saqlash

Abstract

Inson ichak mikrobiotasi sog‘liq va kasalliklarning rivojlanishida markaziy rol o‘ynaydi. Ushbu mikrobiota tarkibi va muvozanati immun tizimi, hazm qilish jarayonlari va metabolik funksiyalar bilan chambarchas bog‘liqdir. Tadqiqot ichak mikrobiotasining fiziologik xususiyatlari, uning sog‘liqni saqlashdagi ahamiyati va turli omillar orqali yuzaga keladigan disbakterioz holatlarini tizimli tahlil qiladi. Shuningdek, probiotiklar va prebiotiklar orqali mikrobiotani modulyatsiya qilish imkoniyatlari ham o‘rganiladi. Tadqiqot natijalari ichak mikrobiotasini tushunish va sog‘liqni saqlash strategiyalarini optimallashtirish uchun ilmiy asoslarni taqdim etadi.

References

1. Sekirov I., Russell S. L., Antunes L. C., Finlay B. B. Gut microbiota in health and disease. Physiological Reviews, 2010; 90(3): 859–904.

2. Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature, 2012; 486: 207–214.

3. Clemente J. C., Ursell L. K., Parfrey L. W., Knight R. The impact of the gut microbiota on human health: an integrative view. Cell, 2012; 148(6): 1258–1270.

4. O’Hara A. M., Shanahan F. The gut flora as a forgotten organ. EMBO Reports, 2006; 7(7): 688–693

5. Valdes A. M., Walter J., Segal E., Spector T. D. Role of the gut microbiota in nutrition and health. BMJ, 2018; 361: k2179.

6. Kau A. L., Ahern P. P., Griffin N. W., Goodman A. L., Gordon J. I. Human nutrition, the gut microbiome, and the immune system. Nature, 2011; 474: 327–336.

7. Guarner F., Malagelada J. R. Gut flora in health and disease. Lancet, 2003; 361: 512–519.

8. Round J. L., Mazmanian S. K. The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews Immunology, 2009; 9: 313–323.

9. Suez J., Zmora N., Segal E., Elinav E. The pros, cons, and many unknowns of probiotics. Nature Medicine, 2019; 25: 716–729.

10. Hill C., Guarner F., Reid G., Gibson G. R., Merenstein D. J., Pot B., Morelli L., Canani R. B., Flint H. J., Salminen S., Calder P. C., Sanders M. E. Expert consensus on the scope and appropriate use of the term probiotic. Nature Reviews Gastroenterology & Hepatology, 2014; 11: 506–514.