Published August 31, 2024
| Version v1
Journal article
Open
SPECIFIC PATHOMORPHOLOGICAL AND IMMUNOPHENOTYPICAL CHARACTERISTICS OF LYMPHOBLASTIC LEUKEMIA IN CHILDREN
- 1. Toshkent tibbiyot akademiyasi Urganch filiali
Description
Ushbu maqola bolalarda limfoblastli leykozlarning (LLL) o‘ziga xos patomorfologik va immunofenotipik xususiyatlarini o‘rganishga bag‘ishlangan. Tadqiqotda 2018-2023-yillar davomida Respublika onkogematologiya markazida LLL tashxisi qo‘yilgan 100 nafar bolalarning klinik, laborator, patomorfologik va immunofenotipik ko‘rsatkichlari tahlil qilindi. Natijalar LLL ning asosiy to‘rt immunologik podtipini ajratib ko‘rsatdi: T-hujayrali, V-hujayrali, T/V gibrid hujayrali va aralash miyeloid-limfoid turlari. Ushbu xususiyatlar bolalarda kasallikning kechishini, davolash strategiyasini va uning samaradorligini belgilashda muhim rol o‘ynaydi.
Files
85-90 Salayeva Zulfiya Shonazarovna.pdf
Files
(616.3 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:7caedfac4c7ef10f2c99d4371c1a4b43
|
616.3 kB | Preview Download |
Additional details
References
- 1. Pui, C. H., & Evans, W. E. (2006). Acute lymphoblastic leukemia. *The New England Journal of Medicine*, 354(2), 166-178. doi:10.1056/NEJMra052603.
- 2. Borowitz, M. J., Rubnitz, J. E., & Shuster, J. J. (2008). Prognostic significance of minimal residual disease in high risk childhood acute lymphoblastic leukemia. *Blood*, 111(12), 5477-5485. doi:10.1182/blood-2007-07-102749.
- 3. Inaba, H., Greaves, M., & Mullighan, C. G. (2013). Acute lymphoblastic leukaemia. *The Lancet*, 381(9881), 1943-1955. doi:10.1016/S0140-6736(12)62187-4.
- 4. Bhojwani, D., Yang, J. J., & Pui, C. H. (2015). Biology of childhood acute lymphoblastic leukemia. *Pediatric Clinics*, 62(1), 47-60. doi:10.1016/j.pcl.2014.09.004.
- 5. Van Vlierberghe, P., & Ferrando, A. (2012). The molecular basis of T cell acute lymphoblastic leukemia. *The Journal of Clinical Investigation*, 122(10), 3398-3406. doi:10.1172/JCI61269.
- 6. Conter, V., Rizzari, C., Sala, A., & Chiesa, R. (2010). Acute lymphoblastic leukemia. In *Pediatric Oncology* (pp. 95-114). Springer, Berlin, Heidelberg. doi:10.1007/978-3-540-69234-1_5.