Keywords
How to Cite
Abstract
Ushbu tadqiqot Peganum harmala L. tarkibidagi β-karbolin alkaloidlaridan biri bo‘lgan harmin asosida N⁹-alkillangan hosilalarni olish va ularning antimikrob xususiyatlarini baholashga qaratilgan. Harmin molekulasining N⁹ holatini maqsadli modifikatsiya qilish uchun metil, etil, n-propil, n-butil va benzil substituentlari tanlandi. N⁹-alkillash jarayoni β-karbolin azotini asos ishtirokida deprotonlash va hosil bo‘lgan nukleofil markazni tegishli alkilgalogenidlar bilan reaksiyaga kiritishga asoslandi. N⁹ metil, N⁹-etil, N⁹-propil, N⁹-butil va N⁹-benzil harmin hosilalarining sintezi, reaksion chiqishlari va spektroskopik xususiyatlari eksperimental adabiyot ma’lumotlari asosida qiyosiy tahlil qilindi.
References
1. Ahmad A., Khan K.A., Sultana S., Siddiqui B.S., Begum S., Faizi S., Siddiqui S. Study of the in vitro antimicrobial activity of harmine, harmaline and their derivatives. Journal of Ethnopharmacology. 1992;35(3):289–294. doi:10.1016/0378 8741(92)90027-O.
2. Nenaah G. Antibacterial and antifungal activities of β-carboline alkaloids of Peganum harmala (L.) seeds and their combination effects. Fitoterapia. 2010;81(7):779–782. doi:10.1016/j.fitote.2010.04.004.
3. Arshad N., Zitterl-Eglseer K., Hasnain S., Hess M. Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytotherapy Research. 2008;22(11):1533–1538. doi:10.1002/ptr.2528.
4. Xing M., Shen F., Liu L., Chen Z., Guo N., Wang X., Wang W., Zhang K., Wu X., Wang X., Li Y., Sun S., Yu L. Antimicrobial efficacy of the alkaloid harmaline alone and in combination with chlorhexidine digluconate against clinical isolates of Staphylococcus aureus grown in planktonic and biofilm cultures. Letters in Applied Microbiology. 2012;54(5):475–482. doi:10.1111/j.1472-765X.2012.03233.x.
5. Lee J.H., Kim Y.G., Shim S.H., Lee J. Antibiofilm activities of norharmane and its derivatives against Escherichia coli O157:H7 and other bacteria. Phytomedicine. 2017;36:254–261. doi:10.1016/j.phymed.2017.10.013.
6. Iranshahy M., Fazly Bazzaz S., Haririzadeh G., Ab
This work is licensed under a Creative Commons Attribution 4.0 International License.
