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Abstract
Birth is the first and arguably the most consequential microbial exposure of a human life. During vaginal delivery, the newborn passes through the birth canal and is inoculated with maternal vaginal and perineal microbiota dominated by Lactobacillus, Prevotella, and Bacteroides species; infants born by cesarean section (C-section) bypass this inoculum and are instead colonized mainly by skin and operating-room associated organisms such as Staphylococcus and Corynebacterium. This early divergence, occurring within a narrow developmental window of immune education, has been proposed as one mechanistic bridge linking the modern rise in C-section rates to the parallel rise in allergic, autoimmune, and metabolic conditions predicted by the hygiene hypothesis.
References
1. Dominguez-Bello MG, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci USA. 2010;107(26):11971–11975.
2. Strachan DP. Hay fever, hygiene, and household size. BMJ. 1989;299:1259–1260.
3. Rook GA. Regulation of the immune system by biodiversity from the natural environment: an ecosystem service essential to health. Proc Natl Acad Sci USA. 2013;110(46):18360–18367.
4. Rutayisire E, Huang K, Liu Y, Tao F. The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review. BMC Gastroenterol. 2016;16:86.
5. Stokholm J, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun. 2018;9:141.
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