Keywords
myocardial inflammation
cardiomyopathy
heart failure
viral infection
How to Cite
Abstract
Myocarditis is an inflammatory disease of the myocardium that can result from a wide range of infectious, autoimmune, toxic, and idiopathic causes. The clinical presentation of myocarditis is highly variable, ranging from mild, self-limiting symptoms to severe acute heart failure, life-threatening arrhythmias, and sudden cardiac death. Viral infections are considered the most common etiological factor, although autoimmune mechanisms and drug-induced myocardial injury are also increasingly recognized. The pathophysiology involves direct myocardial injury and immune-mediated inflammatory responses leading to myocyte necrosis and ventricular dysfunction. Early diagnosis remains challenging due to nonspecific clinical manifestations and limitations of diagnostic tools. This article provides a comprehensive overview of the etiology, pathophysiological mechanisms, clinical features, and current approaches to the management of myocarditis, emphasizing the importance of early recognition and individualized treatment strategies
References
1. Caforio A.L.P., Pankuweit S., Arbustini E., et al. Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis. European Heart Journal. 2013;34(33):2636–2648.
2. Cooper L.T. Myocarditis. New England Journal of Medicine. 2009;360(15):1526–1538.
3. Pollack A., Kontorovich A.R., Fuster V., Dec G.W. Viral myocarditis—diagnosis, treatment options, and current controversies. Circulation. 2015;131(18):163–173.
4. Bozkurt B., Colvin M., Cook J., et al. Current diagnostic and treatment strategies for specific dilated cardiomyopathies. Journal of the American College of Cardiology. 2016;67(21):2556–2568.
5. Ammirati E., Veronese G., Brambatti M., et al. Fulminant versus acute nonfulminant myocarditis in patients with left ventricular systolic dysfunction. Journal of the American College of Cardiology. 2019;74(3):357–368
6. Heymans S., Eriksson U., Lehtonen J., Cooper L.T. The quest for new approaches in myocarditis and inflammatory cardiomyopathy. Journal of the American College of Cardiology. 2016;68(21):2348–2364.
7. Sagar S., Liu P.P., Cooper L.T. Myocarditis. The Lancet. 2012;379(9817):738–747.
8. Friedrich M.G., Sechtem U., Schulz-Menger J., et al. Cardiovascular magnetic resonance in myocarditis: A JACC White Paper. Journal of the American College of Cardiology. 2009;53(17):1475–1487.
9. Blauwet L.A., Cooper L.T. Myocarditis. Progress in Cardiovascular Diseases. 2010;52(4):274–288.
10. Rose N.R. Myocarditis: infection versus autoimmunity. Journal of Clinical Immunology. 2009;29(6):730–737.
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